AWS Introduces Global Cross-Region Inference for Anthropic Claude 4.5 Models in Amazon Bedrock

Amazon Bedrock now supports global cross-region inference for Claude 4.5 models, enabling AI deployment in South Africa with automated request routing.

According to an AWS blog post, Amazon Bedrock now supports scaling AI applications in South Africa through global cross-region inference capabilities with Anthropic’s Claude 4.5 models.

The announcement details technical implementation guidance for developers, including how global cross-region inference routes requests and handles data residency considerations. According to the source, the system uses a global inference profile Amazon Resource Name (ARN) to invoke Claude 4.5 models.

The blog post provides a walkthrough covering the necessary AWS Identity and Access Management (IAM) permissions configuration required to use this feature. This infrastructure enhancement appears designed to help organizations deploy AI applications with improved regional availability and performance routing.

The integration specifically targets South Africa, expanding Amazon Bedrock’s geographical reach for Claude 4.5 model access. The global cross-region inference capability represents AWS’s approach to managing model availability across different geographical regions while maintaining data governance requirements.

This development is part of Amazon Bedrock’s broader managed AI service offerings, which provide access to foundation models including Anthropic’s Claude series through AWS infrastructure.